The Effect on Gastric Emptying of Telaprevir-Based Triple Therapy for Chronic Hepatitis C Patients

• Main Authors: Arata Oyamada (Author), Makoto Arai (Author), Tomoaki Matumura (Author), Kenichiro Okimoto (Author), Shoko Minemura (Author), Keiko Saito (Author), Daisuke Maruoka (Author), Tomoo Nakagawa (Author), Tatsuo Kanda (Author), Tatsuro Katsuno (Author), Osamu Yokosuka (Author)
• Format: Book
• Published: Archives of Clinical Gastroenterology - Peertechz Publications, 2015-07-27.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Aim: </strong>We evaluated food intake in telaprevir-based triple therapy (telaprevir, pegylated-interferon, and ribavirin) and its relation to Gastric Emptying (GE). <br></p><p><strong>Methods: </strong>17 patients received telaprevir combined with pegylated interferon plus ribavirin. The GE study was carried out using the 13C-acetate breath test and GE time was expressed as the peak time of 13CO2 excretion (Tmax). <br></p><p><strong>Results: </strong>The average food intake was 1,851 ± 91, 1,338 ± 537 and 1,453 ± 537 kcal at 0, 1, and 2 weeks after the start of treatment, respectively, showing a significant decrease compared to that before treatment (p < 0.01 and p <0.05, paired t-test). The averages of Tmax values at 0, 1, and 2 weeks after the start of treatment were 48.4 ± 14.3 min, 56.9 ± 18.4 min and 58.0 ± 19.9 min, respectively. There was a significant difference between baseline and 1 week after the start of treatment (p<0.05, paired t-test). Food intake (kcal) showed a good correlation with the decrease of Tmax values (minutes) (Pearson's correlation test, r = -0.49, p < 0.05). </p><p><strong>Conclusions: </strong>Telaprevir-based triple therapy caused reduced food intake and worsened GE.</p>