The Effect on Gastric Emptying of Telaprevir-Based Triple Therapy for Chronic Hepatitis C Patients
<p><strong>Aim: </strong>We evaluated food intake in telaprevir-based triple therapy (telaprevir, pegylated-interferon, and ribavirin) and its relation to Gastric Emptying (GE). <br></p><p><strong>Methods: </strong>17 patients received telaprevir combi...
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Archives of Clinical Gastroenterology - Peertechz Publications,
2015-07-27.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_2455-2283_000003 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Arata Oyamada |e author |
700 | 1 | 0 | |a Makoto Arai |e author |
700 | 1 | 0 | |a Tomoaki Matumura |e author |
700 | 1 | 0 | |a Kenichiro Okimoto |e author |
700 | 1 | 0 | |a Shoko Minemura |e author |
700 | 1 | 0 | |a Keiko Saito |e author |
700 | 1 | 0 | |a Daisuke Maruoka |e author |
700 | 1 | 0 | |a Tomoo Nakagawa |e author |
700 | 1 | 0 | |a Tatsuo Kanda |e author |
700 | 1 | 0 | |a Tatsuro Katsuno |e author |
700 | 1 | 0 | |a Osamu Yokosuka |e author |
245 | 0 | 0 | |a The Effect on Gastric Emptying of Telaprevir-Based Triple Therapy for Chronic Hepatitis C Patients |
260 | |b Archives of Clinical Gastroenterology - Peertechz Publications, |c 2015-07-27. | ||
520 | |a <p><strong>Aim: </strong>We evaluated food intake in telaprevir-based triple therapy (telaprevir, pegylated-interferon, and ribavirin) and its relation to Gastric Emptying (GE). <br></p><p><strong>Methods: </strong>17 patients received telaprevir combined with pegylated interferon plus ribavirin. The GE study was carried out using the 13C-acetate breath test and GE time was expressed as the peak time of 13CO2 excretion (Tmax). <br></p><p><strong>Results: </strong>The average food intake was 1,851 ± 91, 1,338 ± 537 and 1,453 ± 537 kcal at 0, 1, and 2 weeks after the start of treatment, respectively, showing a significant decrease compared to that before treatment (p < 0.01 and p <0.05, paired t-test). The averages of Tmax values at 0, 1, and 2 weeks after the start of treatment were 48.4 ± 14.3 min, 56.9 ± 18.4 min and 58.0 ± 19.9 min, respectively. There was a significant difference between baseline and 1 week after the start of treatment (p<0.05, paired t-test). Food intake (kcal) showed a good correlation with the decrease of Tmax values (minutes) (Pearson's correlation test, r = -0.49, p < 0.05). </p><p><strong>Conclusions: </strong>Telaprevir-based triple therapy caused reduced food intake and worsened GE.</p> | ||
540 | |a Copyright © Arata Oyamada et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/2455-2283.000003 |z Connect to this object online. |