Anal adenosquamous carcinoma on perineal fistula: A case report
<p>Introduction: Adenosquamous Carcinoma (ASC) of the anus presenting both glandular and squamous histopathologic features is a rare colorectal neoplasm.</p><p>Case presentation: A 63-year-old man presented with a one-year history of intermittent rectal pain and bleeding on a perin...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Archives of Clinical Gastroenterology - Peertechz Publications,
2023-03-24.
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| Summary: | <p>Introduction: Adenosquamous Carcinoma (ASC) of the anus presenting both glandular and squamous histopathologic features is a rare colorectal neoplasm.</p><p>Case presentation: A 63-year-old man presented with a one-year history of intermittent rectal pain and bleeding on a perineal fistula. Pathological analysis of the surgical specimen revealed adenosquamous carcinoma of the anus, The patient received neoadjuvant treatment with chemotherapy and radiotherapy over a period of five weeks. then he underwent abdominoperineal resection and a permanent colostomy. Histology revealed invasive adenosquamous carcinoma on the resection specimen and the patient was started on adjuvant therapy with FOLFIRINOX.</p><p>Discussion: Primary ASC of the colon and rectum are extremely rare clinical entities with poor prognosis. Most of the data come from individual case reports and a few small series, making it a challenge to understand the histogenesis of the disease. And the treatment modalities are not yet well codified, which has an impact on overall survival.</p><p>Conclusion: Early diagnosis and radical surgery with other available therapeutic modalities can improve clinical outcomes.</p> |
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| DOI: | 10.17352/2455-2283.000116 |