Anal adenosquamous carcinoma on perineal fistula: A case report

• Main Authors: Hajri Amal (Author), Lamnaouar Abderrahmane (Author), Falousse Kabira (Author), Erreguibi Driss (Author), Boufettal Rachid (Author), Saad Rifki El Jay (Author), Farid Chehab (Author)
• Format: Book
• Published: Archives of Clinical Gastroenterology - Peertechz Publications, 2023-03-24.
• Subjects: Case Report
• Online Access: Connect to this object online.

<p>Introduction: Adenosquamous Carcinoma (ASC) of the anus presenting both glandular and squamous histopathologic features is a rare colorectal neoplasm.</p><p>Case presentation: A 63-year-old man presented with a one-year history of intermittent rectal pain and bleeding on a perineal fistula. Pathological analysis of the surgical specimen revealed adenosquamous carcinoma of the anus, The patient received neoadjuvant treatment with chemotherapy and radiotherapy over a period of five weeks. then he underwent abdominoperineal resection and a permanent colostomy. Histology revealed invasive adenosquamous carcinoma on the resection specimen and the patient was started on adjuvant therapy with FOLFIRINOX.</p><p>Discussion: Primary ASC of the colon and rectum are extremely rare clinical entities with poor prognosis. Most of the data come from individual case reports and a few small series, making it a challenge to understand the histogenesis of the disease. And the treatment modalities are not yet well codified, which has an impact on overall survival.</p><p>Conclusion: Early diagnosis and radical surgery with other available therapeutic modalities can improve clinical outcomes.</p>