HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature

• Main Authors: Meriem N Mrabent (Author), Noria Harir (Author), Feriel Sellam (Author), Soumia Zeggai (Author), Abdenacer Tou (Author), Mustapha Diaf (Author), Rachida Salah (Author), Soraya Moulesshoul (Author)
• Format: Book
• Published: Journal of Surgery and Surgical Research - Peertechz Publications, 2015-10-28.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Background: </strong>To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer.</p><p><strong>Materials and methods:</strong> Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2.</p><p><strong>Results: </strong>The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study.</p><p><strong>Conclusion: </strong>Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.</p>