Acute Effect of Aliskiren on Smoking-Induced Endothelial Dysfunction in Smoker
<p><strong>Background: </strong>We aimed to examine the acute effect of aliskiren on smoking-induced endothelial dysfunction in smoker.</p><p><strong>Methods: </strong>Nineteen male smokers were enrolled. After all participants smoked a cigarette, their endo...
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Format: | Book |
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Journal of Cardiovascular Medicine and Cardiology - Peertechz Publications,
2014-10-27.
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Summary: | <p><strong>Background: </strong>We aimed to examine the acute effect of aliskiren on smoking-induced endothelial dysfunction in smoker.</p><p><strong>Methods: </strong>Nineteen male smokers were enrolled. After all participants smoked a cigarette, their endothelial function was assessed with brachial artery flow mediated dilation (FMD). An hour after the administration of aliskiren, they smoked again, their FMD was assessed again. A month later, all measurements were performed again without the administration of aliskiren as a control. Blood pressure, plasma renin activity, and serum interleukin-6 concentration were also examined at the same time of FMD measurement.</p><p><strong>Results:</strong> A cigarette smoking led to an acute endothelial dysfunction (6.5 ± 1.7% to 3.4 ± 1.0 %, P = 0.02). Aliskiren administration significantly suppressed blood pressure and plasma renin activity, furthermore, improved FMD (6.7 ± 0.5% to 8.1 ± 0.8 %, P = 0.03). Aliskiren significantly reduced serum interleukin-6 concentration, but not in control.</p><p><strong>Conclusion:</strong> Aliskiren has a beneficial effect on smoking-induced acute endothelial dysfunction.</p> |
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DOI: | 10.17352/2455-2976.000010 |