Sacubitril/Valsartan versus enalapril in nonischemic heart failure in Paradigm-Hf trial
<p>Background: We compared the angiotensin receptor-neprilysin inhibitor LCZ696 (sacubitril/valsartan) with enalapril in patients who had nonischemic heart failure with a reduced ejection fraction. </p><p>Methods: In this double-blind trial, we randomly assigned 8442 patients with...
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Journal of Cardiovascular Medicine and Cardiology - Peertechz Publications,
2018-10-18.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_2455-2976_000070 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Mohammed Habib |e author |
245 | 0 | 0 | |a Sacubitril/Valsartan versus enalapril in nonischemic heart failure in Paradigm-Hf trial |
260 | |b Journal of Cardiovascular Medicine and Cardiology - Peertechz Publications, |c 2018-10-18. | ||
520 | |a <p>Background: We compared the angiotensin receptor-neprilysin inhibitor LCZ696 (sacubitril/valsartan) with enalapril in patients who had nonischemic heart failure with a reduced ejection fraction. </p><p>Methods: In this double-blind trial, we randomly assigned 8442 patients with class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either LCZ696 (at a dose of 200 mg twice daily) or enalapril (at a dose of 10 mg twice daily), in addition to recommended therapy. The primary outcome was a composite of death from cardiovascular causes or hospitalization for heart failure, but the trial was designed to detect a difference in the rates of death from cardiovascular causes.</p><p>Results: The trial was stopped early, according to prespecified rules, after a median follow up of 27 months, because the boundary for an overwhelming benefit with LCZ696 had been crossed. The ischemic patients were 5036 (60%) patients and non-ischemic patients were 3363 (40%) patients. In ischemic and in non-ischemic group the LCZ696 was superior to enalapril for reduce primary outcome and CV death (P< 0.001). In LCZ696 group: the primary outcome had occurred in 339 patients (20.16 %) in the non-ischemic group and 575 patients (22.9 %) in the ischemic group (P: 0.03). A total of 199 patients (11.8%) in non-ischemic group and 359 patients in ischemic group (14.3%) died from cardiovascular causes (P: 0.01). and no significant difference between in CV death and primary outcome in enalapril group in the ischemic and non-ischemic patients</p><p>Conclusions: LCZ696 was superior to enalapril in reducing the risks of cardiovascular death and hospitalization for heart failure in ischemic and non-ischemic heart failure.</p> | ||
540 | |a Copyright © Mohammed Habib et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/2455-2976.000070 |z Connect to this object online. |