Lidocaine Infusion Decreases Pain Scores in a Fibromyalgia Pain Population with Signifi cant Differential Pain Relief Secondary to Smoking Status
<p><strong>Study Objective: </strong>Our hypothesis is that systemic lidocaine can significantly reduce chronic pain associated with fibromyalgia. A secondary goal of the study is to determine if other patient demographics can affect the response to IV lidocaine.</p><p>...
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| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Βιβλίο |
| Έκδοση: |
Global Journal of Anesthesiology - Peertechz Publications,
2017-04-21.
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| Περίληψη: | <p><strong>Study Objective: </strong>Our hypothesis is that systemic lidocaine can significantly reduce chronic pain associated with fibromyalgia. A secondary goal of the study is to determine if other patient demographics can affect the response to IV lidocaine.</p><p><strong>Design:</strong> Retrospective chart review</p><p><strong>Setting: </strong>Outpatient pain clinic</p><p><strong>Patients: </strong>55 patients being treated for fibromyalgia by lidocaine infusion Interventions: Intravenous infusion of lidocaine 5mg/kg over 1 hour Measurements: Two-tailed paired t-tests (α=0.05) were performed to test for significant change from pre- to post-infusion in BPI, PI, and VAS scores. Smoking status and race classification were also identified.</p><p><strong>Main Results:</strong> Mean BPI score decreased from 83.2±16.5 to 73.7±21.6 after infusion of 4 to 5 mg/ kg of lidocaine in 500 ml 5% dextrose (p-value<0.0001). Mean VAS decreased from 7.6±1.6 to 5.8±2.2 (p<0.0001). The post-infusion BPI was significantly lower in non-smokers 68.5 ±19.6 vs. smokers 80.3 ±17.2 (p=0.028) and Caucasians 69.3 ±20.3 vs. African-Americans 83.6±21.4 (p=0.027).</p><p><strong>Conclusions: </strong>A retrospective analysis of 55 fibromyalgia patients who received IV lidocaine shows a statistically significant decrease in pain scores. A subgroup analysis shows that baseline pain scores are higher in smokers, and response to IV lidocaine is attenuated in smokers compared to non-smokers.</p> |
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| DOI: | 10.17352/2455-3476.000032 |