Lidocaine Infusion Decreases Pain Scores in a Fibromyalgia Pain Population with Signifi cant Differential Pain Relief Secondary to Smoking Status

• मुख्य लेखकों: Yang Hyung Kim (लेखक), Dan Moyse (लेखक), Christian Horazeck (लेखक), Hung-Lun Hsia (लेखक), Carlos J Roldan (लेखक), Billy Huh (लेखक), Lance Roy (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Global Journal of Anesthesiology - Peertechz Publications, 2017-04-21.
• विषय: Case Report
• ऑनलाइन पहुंच: Connect to this object online.

<p><strong>Study Objective: </strong>Our hypothesis is that systemic lidocaine can significantly reduce chronic pain associated with fibromyalgia. A secondary goal of the study is to determine if other patient demographics can affect the response to IV lidocaine.</p><p><strong>Design:</strong> Retrospective chart review</p><p><strong>Setting: </strong>Outpatient pain clinic</p><p><strong>Patients: </strong>55 patients being treated for fibromyalgia by lidocaine infusion Interventions: Intravenous infusion of lidocaine 5mg/kg over 1 hour Measurements: Two-tailed paired t-tests (α=0.05) were performed to test for significant change from pre- to post-infusion in BPI, PI, and VAS scores. Smoking status and race classification were also identified.</p><p><strong>Main Results:</strong> Mean BPI score decreased from 83.2±16.5 to 73.7±21.6 after infusion of 4 to 5 mg/ kg of lidocaine in 500 ml 5% dextrose (p-value<0.0001). Mean VAS decreased from 7.6±1.6 to 5.8±2.2 (p<0.0001). The post-infusion BPI was significantly lower in non-smokers 68.5 ±19.6 vs. smokers 80.3 ±17.2 (p=0.028) and Caucasians 69.3 ±20.3 vs. African-Americans 83.6±21.4 (p=0.027).</p><p><strong>Conclusions: </strong>A retrospective analysis of 55 fibromyalgia patients who received IV lidocaine shows a statistically significant decrease in pain scores. A subgroup analysis shows that baseline pain scores are higher in smokers, and response to IV lidocaine is attenuated in smokers compared to non-smokers.</p>