Evaluation of Dopamine Receptor Integrity after Sevofl urane Exposure in Neonatal Rat Brain Using Positron Emission Tomography
<p><strong>Aims:</strong> The volatile general anesthetic sevofl urane is commonly used across all ages in the clinic. Sevofl urane-induced neurotoxic effects on the developing dopaminergic system are still unclear. The aim of this study was to evaluate the integrity of the D2/D3 r...
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Global Journal of Anesthesiology - Peertechz Publications,
2018-01-18.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_2455-3476_000040 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Qi Yin |e author |
| 700 | 1 | 0 | |a Merle G. Paule |e author |
| 700 | 1 | 0 | |a Tucker A. Patterson |e author |
| 700 | 1 | 0 | |a Fang Liu |e author |
| 700 | 1 | 0 | |a Charles M. Fogle |e author |
| 700 | 1 | 0 | |a Scott M. Apana |e author |
| 700 | 1 | 0 | |a Marc Berridge |e author |
| 700 | 1 | 0 | |a William Slikker Jr |e author |
| 700 | 1 | 0 | |a Cheng Wang |e author |
| 700 | 1 | 0 | |a Xuan Zhang |e author |
| 245 | 0 | 0 | |a Evaluation of Dopamine Receptor Integrity after Sevofl urane Exposure in Neonatal Rat Brain Using Positron Emission Tomography |
| 260 | |b Global Journal of Anesthesiology - Peertechz Publications, |c 2018-01-18. | ||
| 520 | |a <p><strong>Aims:</strong> The volatile general anesthetic sevofl urane is commonly used across all ages in the clinic. Sevofl urane-induced neurotoxic effects on the developing dopaminergic system are still unclear. The aim of this study was to evaluate the integrity of the D2/D3 receptor in developing rat brain utilizing molecular imaging techniques. </p><p><strong>Method:</strong> Positron Emission Tomography (PET) coupled with Computerized Tomography (CT) approaches were used to evaluate the effects of developmental sevofl urane exposure on D2/D3 receptors in rat pups. The PET radiotracer, [18F]-fallypride, was used to examine whether dopamine receptors were affected by prolonged sevofl urane-exposure during the brain growth spurt. Six postnatal day (PND) 7 rats in the experimental group were exposed to sevofl urane at the clinically-relevant concentration of 2.5% (v/v) for 8 hours, and an equal number of control animals were exposed to room air for 8 hours. MicroPET/CT scans were sequentially collected on PNDs 14, 21, 28, and 35.</p><p><strong>Results:</strong> No signifi cant differences in the retention of [18F]-fallypride in striatum were detected between sevofl urane-exposed and control animals at any of the scan times. D2/D3 receptors are not affected by prolonged sevofl urane-induced general anesthesia during development.</p><p><strong>Conclusions:</strong> Sevofl urane-induced neurotoxicity in the developing rodent brain was not associated with apparent derangements in dopamine D2/D3 receptors.</p> | ||
| 540 | |a Copyright © Qi Yin et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Research Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/2455-3476.000040 |z Connect to this object online. |