Comparison of dexamethasone, granisetron and haloperidol in prevention of postoperative nausea and vomiting following laparoscopic surgeries: A prospective, double-blinded study

• Main Authors: Shikha Sharma (Author), Gnanasekar N (Author), Pranjali Kurhekar (Author)
• Format: Book
• Published: Global Journal of Anesthesiology - Peertechz Publications, 2019-03-29.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p>Background: Laparoscopic surgeries are most commonly performed surgeries. However, they are associated with increased incidences of postoperative nausea and vomiting. </p><p>Aim: We aimed to compare the effectiveness of dexamethasone, haloperidol, granisetron in prevention of postoperative nausea and vomiting following laparoscopic surgeries. </p><p>Methods: We conducted a randomized, double-blinded study including 90 patients both males and females undergoing laparoscopic surgeries in a tertiary hospital over 18 months. The subjects were randomized into three groups. Group I Dexamethasone 8mg, Group II Granisetron 2mg, Group III Haloperidol 1mg (n=30 each group). The study drugs were administered intravenously immediately after intubation. Patients were observed every 4th hourly till 24 hours for incidence of nausea, vomiting, pain and sedation. </p><p>Results: Incidence of vomiting was significantly less in dexamethasone group (p=0.047) as compared to granisetron and haloperidol and was statistically significant (p<0.047).There was no significant difference in the incidence of vomiting between other two groups. All other parameters were comparable in all the groups. </p><p>Conclusion: Dexamethasone in the dose of 8mg significantly reduces incidence of vomiting in laparoscopic surgeries than haloperidol and granisetron. </p><p>Trial Registry: Clinical Trial Registry of India 2018/03/018324</p>

DOI

10.17352/2455-3476.000045