How the histamine N-methyltransferase inhibitor metoprine alleviates methamphetamine reward
<p>Methamphetamine (METH) is a highly addictive psychomotor stimulant drug that is abused worldwide [1].<br>METH abuse results in numerous adverse effects after acute administration, as well as an array of adverse outcomes associated with binge use, long-term use, and withdrawal [2- 4]....
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Journal of Addiction Medicine and Therapeutic Science - Peertechz Publications,
2017-05-12.
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|---|---|---|---|
| 001 | peertech__10_17352_2455-3484_000021 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Nobue Kitanaka |e author |
| 700 | 1 | 0 | |a Junichi Kitanaka |e author |
| 700 | 1 | 0 | |a F Scott Hall |e author |
| 700 | 1 | 0 | |a Satoshi Okumura# |e author |
| 700 | 1 | 0 | |a Tomoyuki Sakamoto# |e author |
| 700 | 1 | 0 | |a George R Uhl |e author |
| 700 | 1 | 0 | |a Motohiko Takemura |e author |
| 245 | 0 | 0 | |a How the histamine N-methyltransferase inhibitor metoprine alleviates methamphetamine reward |
| 260 | |b Journal of Addiction Medicine and Therapeutic Science - Peertechz Publications, |c 2017-05-12. | ||
| 520 | |a <p>Methamphetamine (METH) is a highly addictive psychomotor stimulant drug that is abused worldwide [1].<br>METH abuse results in numerous adverse effects after acute administration, as well as an array of adverse outcomes associated with binge use, long-term use, and withdrawal [2- 4]. Acutely METH releases dopamine from synaptic terminals through multiple actions that include inducing reverse transport of dopamine via the dopamine transporter (DAT), impairing the function of the vesicular monoamine transporter-2 (VMAT2), leading to increased cytoplasmic dopamine concentrations,<br>and inhibition of monoamine oxidase [5-8]. Moreover, these changes contribute to the production of oxidative metabolites, metabolic impairments, oxidative damage to dopamine terminals, and depletion of tissue dopamine levels [9-11]. METH and related drugs consequently produce broad effects on the central nervous system both acutely and chronically [12-14].<br></p> | ||
| 540 | |a Copyright © Nobue Kitanaka et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Review Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/2455-3484.000021 |z Connect to this object online. |