Design of Peptide Models for β-Hairpins and Equilibrating Helix-Hairpin Structures

• Main Authors: Chinnasamy Selvakkumar (Author), Eashwarwark Vikram Reddy (Author), Kesavanarayanan Krishnan Selvarajan (Author), Nazeerullah Rahamuthullah (Author), Muftha Mohamed Zarmouh (Author)
• Format: Book
• Published: International Journal of Nanomaterials, Nanotechnology and Nanomedicine - Peertechz Publications, 2016-05-04.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p>It is well established that synthetic peptides containing a centrally positioned Type-I or Type-II β-turn can form well folded peptide hairpins (1). Earlier studies from this laboratory have established that D-Pro-Xxx segments nucleate β-hairpin structures, with formation of a central Type-II β-turn (2). The octapeptide (Boc-Leu-Phe-Val-Aib-D-Ala-Leu-Phe- Val-OMe) is a rare example of a synthetic peptide hairpin, containing a central Type-I β-turn. Hairpins with Type-I turns are considerably more twisted than their Type-II counterparts. The Aib-Xxx segment has also been shown to adopt a Type-I β-turn structure, resulting in incorporation into the centre of a long synthetic, helical peptide (3) (Figures 1,2). </p><p><br></p>

DOI

10.17352/2455-3492.000009