Design of Peptide Models for β-Hairpins and Equilibrating Helix-Hairpin Structures
<p>It is well established that synthetic peptides containing a centrally positioned Type-I or Type-II β-turn can form well folded peptide hairpins (1). Earlier studies from this laboratory have established that D-Pro-Xxx segments nucleate β-hairpin structures, with formation of a central Type-...
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Livre |
| Publié: |
International Journal of Nanomaterials, Nanotechnology and Nanomedicine - Peertechz Publications,
2016-05-04.
|
| Sujets: | |
| Accès en ligne: | Connect to this object online. |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_2455-3492_000009 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Chinnasamy Selvakkumar |e author |
| 700 | 1 | 0 | |a Eashwarwark Vikram Reddy |e author |
| 700 | 1 | 0 | |a Kesavanarayanan Krishnan Selvarajan |e author |
| 700 | 1 | 0 | |a Nazeerullah Rahamuthullah |e author |
| 700 | 1 | 0 | |a Muftha Mohamed Zarmouh |e author |
| 245 | 0 | 0 | |a Design of Peptide Models for β-Hairpins and Equilibrating Helix-Hairpin Structures |
| 260 | |b International Journal of Nanomaterials, Nanotechnology and Nanomedicine - Peertechz Publications, |c 2016-05-04. | ||
| 520 | |a <p>It is well established that synthetic peptides containing a centrally positioned Type-I or Type-II β-turn can form well folded peptide hairpins (1). Earlier studies from this laboratory have established that D-Pro-Xxx segments nucleate β-hairpin structures, with formation of a central Type-II β-turn (2). The octapeptide (Boc-Leu-Phe-Val-Aib-D-Ala-Leu-Phe- Val-OMe) is a rare example of a synthetic peptide hairpin, containing a central Type-I β-turn. Hairpins with Type-I turns are considerably more twisted than their Type-II counterparts. The Aib-Xxx segment has also been shown to adopt a Type-I β-turn structure, resulting in incorporation into the centre of a long synthetic, helical peptide (3) (Figures 1,2). </p><p><br></p> | ||
| 540 | |a Copyright © Chinnasamy Selvakkumar et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Research Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/2455-3492.000009 |z Connect to this object online. |