Sonographic appearances of the kidneys and correlation with CD4 count and viral load in adult HIV/AIDS patients in a rural-based infectious disease hospital in sub-saharan Africa
<p>Background: The management of HIV infection is often challenging as it can affect every organ in the body including the kidneys. Determination of the Resistivity Indices (RI) of the intra-renal arteries is an emerging non-invasive tool that could predict renal disease. </p><p>Ai...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Book |
Published: |
Journal of HIV for Clinical and Scientific Research - Peertechz Publications,
2023-11-16.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | peertech__10_17352_2455-3786_000036 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Ehi-Imuse AJ |e author |
700 | 1 | 0 | |a Adeyekun AA |e author |
700 | 1 | 0 | |a Irabor PFI |e author |
700 | 1 | 0 | |a Azubike CO |e author |
700 | 1 | 0 | |a Izevbekhai SO |e author |
245 | 0 | 0 | |a Sonographic appearances of the kidneys and correlation with CD4 count and viral load in adult HIV/AIDS patients in a rural-based infectious disease hospital in sub-saharan Africa |
260 | |b Journal of HIV for Clinical and Scientific Research - Peertechz Publications, |c 2023-11-16. | ||
520 | |a <p>Background: The management of HIV infection is often challenging as it can affect every organ in the body including the kidneys. Determination of the Resistivity Indices (RI) of the intra-renal arteries is an emerging non-invasive tool that could predict renal disease. </p><p>Aims & objectives: To determine the renal volume, parenchymal pattern, as well as the RI of the intra-renal arteries by Doppler ultrasonography in adult HIV/AIDS patients and correlate findings with CD4 count, viral load and serum creatinine.</p><p>Materials & methods: This is a comparative cross-sectional descriptive study that involved sonographic assessment of the renal dimensions, parenchymal echogenicity, and Doppler velocimetry of the segmental intra-renal arteries in 100 apparently healthy confirmed HIV-seronegative control subjects and an equal number of confirmed HIV-seropositive adult patients at Retroviral (RV) clinic of our hospital. A Doppler ultrasound machine with a 3.5MHz Curvilinear probe was used. </p><p>Data analysis: Data obtained was analyzed and presented as means which were compared using Student's t - test, and p values < 0.05 at 95% intervals were considered significant. Pearson's correlation coefficient was used to assess correlation.</p><p>Results: The renal volumes were larger in the HIV/AIDS subjects (right: 125.94 ± 34.02 cm3 and left: 138.99 ± 33.29cm3) than in controls (p = < 0.01) with the left also larger than the right in both HIV/AIDS and control subjects (p = < 0.01, < 0.01) respectively. </p><p>There were significantly more individuals with abnormal renal echogenicity in the HIV/AIDS subjects than in the controls.</p><p>The RI was significantly greater in the HIV/AIDS than in control subjects.</p><p> Both renal volumes showed a weak negative correlation with CD4, viral load, and serum creatinine which was not statistically significant. </p><p>There was a statistically significant weak negative correlation between renal echogenicity and CD4 but a positive correlation with viral load and serum creatinine. </p><p>RI showed weak negative correlations with serum creatinine and weak positive correlations with CD4 count. </p><p>Conclusion: There is a significant difference in renal volume, echogenicity, and RI in HIV/AIDS patients compared to the controls. Renal echogenicity is a better predictor of serum creatinine levels than renal volume and RI. Thus, renal volume and RI do not provide sufficient correlation to be used as a means of monitoring HIV/AIDS patients with renal impairment.</p> | ||
540 | |a Copyright © Ehi-Imuse AJ et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/2455-3786.000036 |z Connect to this object online. |