The Diagnostic value of FibroScan for the degree of liver fibrosis in patients with ALT<2×ULN chronic hepatitis B

• Main Authors: Wenjian Shi (Author), Tuanjie Che (Author), Chun Li (Author), Caidong Li (Author), Yan Zhang (Author), Xiaoling Li (Author), Zhong jia (Author), Hong Wan (Author)
• Format: Book
• Published: Global Journal of Medical and Clinical Case Reports - Peertechz Publications, 2020-05-16.
• Subjects: Case Report
• Online Access: Connect to this object online.

<p>Objective: This paper studied the diagnostic value of FibroScan (FS) for the degree of liver fibrosis in patients with ALT<2×ULN chronic hepatitis B(CHB).</p><br><p>Methods: 100 ALT<2×ULN CHB patients, who also with liver biopsy in our hospital from January 2017 to May 2019 were enrolled. According to the results of liver biopsy, patients that below G2 were classified as mild inflammation group. patients that above G2 were classified as moderate inflammation group; patients that below S2 were designated as non-significant fibrosis group, patients that above S2 and equal to S2 were designated as significant fibrosis group, then compared it with the results of Liver Stiffness Measurement (LSM) which measured by FS respectively.</p><br><p>Results: 91 out of 100 patients had complete data, there were 60 patients in mild liver inflammation group, 31 in the moderate inflammation group, 53 patients belong to no significant fibrosis group and 17 patients belong to significant fibrosis group, comparison, there were statistically significant between the two groups of LSM (Z= 3.303, P = 0.001; Z= 4.944, P < 0.001); FS diagnosis of significant liver fibrosis area under the curve (ACU) were 0.851, 95% CI (0.765-0.937), when the Yoden index is 0.59, the LSM optimal cut-off value is 5.35, and the corresponding sensitivity value is 86.4%, the specificity value is 72.5%.</p><br><p>Conclusion: For patients with ALT<2×ULN CHB, the liver stiffness measurement (LSM) measured by FS is related to the degree of fibrosis in the liver tissue. When the optimal cut-off value of LSM is 5.35, its diagnosis is most effective in significant liver fibrosis.</p>