Complete response of merkel cell carcinoma with brain metastases to pembrolizumab and radiotherapy: A case report
<p>Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progress...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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Global Journal of Medical and Clinical Case Reports - Peertechz Publications,
2021-06-03.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progression-free survival of only 3 months [2,3]. Even though Merkel cell carcinoma frequently shows lymphatic metastases, it almost never shows cerebral involvement [1]. To our knowledge there are only twelve reported cases of cerebral metastases. Furthermore this is the first reported case of complete response in a patient with advanced Merkel cell carcinoma Stage IV with brain metastases under combined treatment with pembrolizumab and radiotherapy.</p><p><br></p> |
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| DOI: | 10.17352/2455-5282.000129 |