Complete response of merkel cell carcinoma with brain metastases to pembrolizumab and radiotherapy: A case report

• Asıl Yazarlar: Ansgar Koechel (Yazar), Franz-Joachim Hilke (Yazar), Bernhard Klumpp (Yazar), Christopher Schroeder (Yazar), Thomas Eigentler (Yazar), Diana Lomberg (Yazar), Claus Garbe (Yazar), Ulrike Leiter (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Global Journal of Medical and Clinical Case Reports - Peertechz Publications, 2021-06-03.
• Konular: Case Report
• Online Erişim: Connect to this object online.

Özet

<p>Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progression-free survival of only 3 months [2,3]. Even though Merkel cell carcinoma frequently shows lymphatic metastases, it almost never shows cerebral involvement [1]. To our knowledge there are only twelve reported cases of cerebral metastases. Furthermore this is the first reported case of complete response in a patient with advanced Merkel cell carcinoma Stage IV with brain metastases under combined treatment with pembrolizumab and radiotherapy.</p><p><br></p>

DOI

10.17352/2455-5282.000129