Complete response of merkel cell carcinoma with brain metastases to pembrolizumab and radiotherapy: A case report
<p>Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progress...
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Global Journal of Medical and Clinical Case Reports - Peertechz Publications,
2021-06-03.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_2455-5282_000129 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ansgar Koechel |e author |
| 700 | 1 | 0 | |a Franz-Joachim Hilke |e author |
| 700 | 1 | 0 | |a Bernhard Klumpp |e author |
| 700 | 1 | 0 | |a Christopher Schroeder |e author |
| 700 | 1 | 0 | |a Thomas Eigentler |e author |
| 700 | 1 | 0 | |a Diana Lomberg |e author |
| 700 | 1 | 0 | |a Claus Garbe |e author |
| 700 | 1 | 0 | |a Ulrike Leiter |e author |
| 245 | 0 | 0 | |a Complete response of merkel cell carcinoma with brain metastases to pembrolizumab and radiotherapy: A case report |
| 260 | |b Global Journal of Medical and Clinical Case Reports - Peertechz Publications, |c 2021-06-03. | ||
| 520 | |a <p>Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progression-free survival of only 3 months [2,3]. Even though Merkel cell carcinoma frequently shows lymphatic metastases, it almost never shows cerebral involvement [1]. To our knowledge there are only twelve reported cases of cerebral metastases. Furthermore this is the first reported case of complete response in a patient with advanced Merkel cell carcinoma Stage IV with brain metastases under combined treatment with pembrolizumab and radiotherapy.</p><p><br></p> | ||
| 540 | |a Copyright © Ansgar Koechel et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Case Report |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/2455-5282.000129 |z Connect to this object online. |