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Glimepiride induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A case report

<p>The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin sec...

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Bibliographic Details
Main Authors: Afia Zainab Tanni (Author), Md Farid Uddin (Author), Shohael Mahmud Arafat (Author), Shahjada Selim (Author), Marufa Mustari (Author), MSI Tipu Chowdhury (Author)
Format: Book
Published: Global Journal of Medical and Clinical Case Reports - Peertechz Publications, 2022-04-30.
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Case Report
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Summary:<p>The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin secretion. Here we described a 55-year-old woman with uncontrolled type 2 diabetes on glimepiride with SIADH presenting with anorexia, asthenia, and altered mental status. After the withdrawal of glimepiride, these symptoms were improved and sodium level returned to a normal value which demand monitoring of serum sodium level during treatment with glimepiride.</p>
DOI:10.17352/2455-5282.000151

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