Impact of the gamma variant on the icu admission in a hospital of the autonomous city of Buenos Aires (Caba), Argentina

• Main Authors: Verónica Mandich (Author), Daniel Chiacchiara (Author), Antonio Pilipec (Author), Santiago Grimaldi (Author), Johnny Cotez (Author), Víctor Paniouk (Author), Oswaldo Escobar (Author), Henry Arévalo (Author), Sebastián Pérez Flach (Author), Amílcar Herbas Pozo (Author), Alejandro Aimar (Author), Marcelo Bravo (Author)
• Format: Book
• Published: Global Journal of Infectious Diseases and Clinical Research - Peertechz Publications, 2021-11-18.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p>Objectives: Comparison between patients admitted to the Intensive Care Unit (ICU) with ventilatory support during the first and second wave (Gamma variant) of COVID 19 in a tertiary hospital in the City of Buenos Aires.</p><p>Design: Descriptive, observational, prospective cohort study.</p><p>Setting: ICU of an acute general hospital in Argentina.</p><p>Patients: Adult patients with COVID-19 admitted consecutively to the ICU.</p><p>Intervention: Admission to ICU.</p><p>Main variables of interest: Demographic and laboratory data, history, duration of MV, mortality.</p><p>Results: 44 patients were recruited during the first wave, and 80 in the second. Significant differences were observed in the second wave for age (60, [SD 11]; vs 68 [SD 11]; p <0.01), days with symptoms (9 [SD 5]; vs 4.5 [SD 3]; p <0.01), duration of MV (10 days [SD 7]; vs 16 [SD 13]; p <0.01), Ferritin (1450 mcg / l [SD 547]; vs 941 mcg / l [ SD 593]; p 0.04) and use of antibiotics (97% vs 45% p <0.01). There was no difference in mortality (66% vs 78% p 0.14) but there was in its primary causes; being more frequent hypoxemia associated with sepsis in the second wave (40% vs 3.4% p <0.01) and hypoxemia and multiorgan failure in the first (28% vs 4% p <0.01).</p><p>Conclusions: During the second wave of the pandemic, due to Gamma variant, more patients were admitted to our unit, younger, with a longer evolution time, a shorter time on MV and a greater inflammatory response, with no difference in mortality, although there was a difference in its causes.</p>

DOI

10.17352/2455-5363.000048