Alteration of brain structural organization after sepsis with Fatigue - a structural brain network analysis
<p>In our recent cross-sectional investigation, we found in sepsis survivors with persistent cognitive impairment a high number of patients who still suffer from Fatigue. This finding is of importance because Fatigue is highlighted as an associated long-term sequela after sepsis and therefore...
Guardado en:
Autores principales: | , , , |
---|---|
Formato: | Libro |
Publicado: |
Archives of Community Medicine and Public Health - Peertechz Publications,
2021-06-07.
|
Materias: | |
Acceso en línea: | Connect to this object online. |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
MARC
LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | peertech__10_17352_2455-5479_000145 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Gundula Seidel |e author |
700 | 1 | 0 | |a Alexander Ritter |e author |
700 | 1 | 0 | |a Florian Bähr |e author |
700 | 1 | 0 | |a Farsin Hamzei |e author |
245 | 0 | 0 | |a Alteration of brain structural organization after sepsis with Fatigue - a structural brain network analysis |
260 | |b Archives of Community Medicine and Public Health - Peertechz Publications, |c 2021-06-07. | ||
520 | |a <p>In our recent cross-sectional investigation, we found in sepsis survivors with persistent cognitive impairment a high number of patients who still suffer from Fatigue. This finding is of importance because Fatigue is highlighted as an associated long-term sequela after sepsis and therefore these patients require an appropriate rehabilitation therapy. </p><p>The aim of this study was to verify whether sepsis survivors with both cognitive impairment and Fatigue show any alteration in brain structure. </p><p>19 survivors of severe sepsis (longer than 2 years post sepsis) with persistent cognitive deficits ascertained with a battery of neuropsychological tests with cognitive and motor Fatigue symptoms (according to two German Fatigue scales) were investigated with a high-resolution. </p><p>T1 weighted image of the brain at a 3.0 Tesla MRI scanner. The Voxel-based morphometry (VBM) was performed using VBM8 toolbox. 19 age- and sex-matched healthy control subjects were also scanned with MRI. </p><p>VBM analysis revealed significant gray matter volume reduction in sepsis survivors particularly in the lateral frontal operculum and anterior cingulate cortex. These regions are part of the cingulo-opercular network which maintains alertness. Gray matter volume loss of the orbitofrontal cortex is functionally associated with Fatigue. </p><p>These findings emphasize that networks of structural brain organization can be altered with corresponding clinical symptoms and neuropsychological deficits after sepsis. </p> | ||
540 | |a Copyright © Gundula Seidel et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/2455-5479.000145 |z Connect to this object online. |