Exercise-induced time-dependent changes in plasma BDNF levels in people with schizophrenia
<p><strong>Objective:</strong> To investigate the short and long-term outcomes of a concurrent exercise protocol</p><p>(CEP) on plasma Brain-derived neurotrophic factor (BDNF) levels and the effect of this intervention in</p><p>the self-esteem and mental hea...
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Main Authors: | , , , , , , , , |
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Format: | Book |
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Journal of Novel Physiotherapy and Physical Rehabilitation - Peertechz Publications,
2018-01-18.
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Summary: | <p><strong>Objective:</strong> To investigate the short and long-term outcomes of a concurrent exercise protocol</p><p>(CEP) on plasma Brain-derived neurotrophic factor (BDNF) levels and the effect of this intervention in</p><p>the self-esteem and mental health in people with schizophrenia (SZ).</p><p><strong>Methods:</strong> In this quasi-experimental study, 15 participants underwent a structured, supervised</p><p>and group based CEP for 12 weeks (the sessions were performed 3 times a week for 60 minutes). In</p><p>order to verify the short- and long-term effects of exercise on BDNF levels, blood samples of 15 ml were</p><p>collected pre-intervention and on the 4th, 8th and 12th week(s) after intervention started. To evaluate</p><p>self-esteem, the Rosemberg Self-esteem Scale was used, and the general mental health status was</p><p>measured through the General Health Questionnaire-12 (GHQ-12). Both questionnaires were applied</p><p>before and after intervention.</p><p><strong>Results:</strong> BDNF plasma levels increased signifi cantly at the 12 th week(s) when compared to</p><p>baseline and in 4 weeks periods. There were no observed changes on self-esteem neither a trend of</p><p>improvement in the GHQ at the post-intervention phase when compared to the baseline. Finally, the</p><p>CEP reduced signifi cantly anthropometric variables.</p><p><strong>Conclusion:</strong> The CEP induced time-dependent modulation on BDNF levels in individuals with SZ,</p><p>increasing its levels only in a long-term period.</p> |
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DOI: | 10.17352/2455-5487.000056 |