Clinical Significance of Hilar Hyalinosis in Glomeruli of Children with Idiopathic Nephrotic Syndrome
<p><strong>Introduction:</strong> Hilar hyalinosis (HH) of glomeruli has been thought for a long time to be a precursor or a variant of focal glomerulosclerosis (FGS). In view of its implications on treatment and prognosis of nephrotic syndrome, a retrospective study of hilar hyali...
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Archives of Renal Diseases and Management - Peertechz Publications,
2015-08-03.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_2455-5495_000003 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Amal AAl-Eisa |e author |
700 | 1 | 0 | |a Thomas M D'souza |e author |
245 | 0 | 0 | |a Clinical Significance of Hilar Hyalinosis in Glomeruli of Children with Idiopathic Nephrotic Syndrome |
260 | |b Archives of Renal Diseases and Management - Peertechz Publications, |c 2015-08-03. | ||
520 | |a <p><strong>Introduction:</strong> Hilar hyalinosis (HH) of glomeruli has been thought for a long time to be a precursor or a variant of focal glomerulosclerosis (FGS). In view of its implications on treatment and prognosis of nephrotic syndrome, a retrospective study of hilar hyalinosis in children with the idiopathic nephrotic syndrome (INS), but without any other histologic evidence of FGS, was performed to determine the clinic-pathologic significance of this lesion.</p><p><strong>Methods: </strong>A total of 92 Children with INS who had kidney biopsies for frequent relapses, steroid dependency or resistance were included. Eight of them had a biopsy-proven diagnosis of either minimal change disease or mild IgM nephropathy with HH in 6-25% of glomeruli were compared to control group consisting of 84 children with either minimal change disease (n=57) or IgM nephropathy (n=27) but without HH.</p><p><strong>Results:</strong> Clinically HH patients presented with NS and followed a steroid-dependent relapsing course prior to biopsy. Around 75% of the HH patients received at least one course of cytotoxic therapy after biopsy. At last visit, 6 patients were in remission, 2 were protein-free but on medication. None had hypertension or renal insufficiency. Apart from having a shorter interval between presentation and biopsy (P<0.001) and a lower remission rate (P<0.05), control patients followed a similar course.Pathologically HH patients showed less mesangial change (P<0.001) than the controls but similar mean glomerular size and tubuloinerstitial damage.</p> | ||
540 | |a Copyright © Amal AAl-Eisa et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/2455-5495.000003 |z Connect to this object online. |