Does Acute Kidney Injury Alter Energy Metabolism of Septic Patients?

• প্রধান লেখক: Ana Cláudia Soncini Sanches (লেখক), Cassiana Regina de Góes (লেখক), Marina Nogueira Berbel Bufarah (লেখক), André Luis Balbi (লেখক), Daniela Ponce (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Archives of Renal Diseases and Management - Peertechz Publications, 2016-07-16.
• বিষয়গুলি: Research Article
• অনলাইন ব্যবহার করুন: Connect to this object online.

<p><strong>Background:</strong> The determination of resting energy expenditure (REE) in critically ill patients is essential to prevent hypo and hyper alimentation. </p><p><strong>Objectives: </strong>This study aims to describe the REE in septic patients with and without acute kidney injury (AKI) and compare by examining the REE estimated by Harris-Benedict equation (HB) with the REE measured by indirect calorimetry (IC).</p><p><strong>Methods:</strong> Prospective study was performed in septic patients older than 18 years, undergoing mechanical ventilation, with or without AKI defined by KDIGO criteria, and admitted to the Intensive Care Unit of University Hospital. The REE was estimated by HB equation and measured by IC within 72 hours after the diagnosis of sepsis and seven days after the initial measure. </p><p><strong>Results: </strong>Sixty-eight patients were evaluated, age was 62.49±16.6 years, 63.2% had AKI, and SOFA was 9.81±2.35. The measured REE was 1857.53±685.32 kcal, while the estimated REE was 1514.87±356.72 kcal, with adequacy of 123.49±43%. Septic patients without AKI (n=25) and with AKI (n=43) had measured REE statistically higher than the estimated one (1855 kcal (1631.75-2052.75) vs. 1551 kcal (1349 -1719.25), p=0.007 and 1868.0 kcal (1219.5-2364.75) vs. 388 kcal(1254-1665.5), p=0.026, respectively). There was no significant difference between the two groups in measured and estimated REE and in evolutional REE.</p>