Potential Impact of Dialysate Magnesium on Intradialytic Hypotension

• Main Authors: Michael S Balzer (Author), Janina Müller-Deile (Author), Daniela I Schulze (Author), Georg Eisenbach (Author), Bernhard MW Schmidt (Author), Hermann Haller (Author), Roland Schmitt (Author)
• Format: Book
• Published: Archives of Renal Diseases and Management - Peertechz Publications, 2016-11-30.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p>Numerous beneficial effects on cardiovascular health have been described for magnesium (Mg). Intradialytic hypotension (IDH) is a common complication in hemodialysis patients which contributes to cardiovascular mortality. It has been suggested that higher dialysate Mg (DMg) might reduce the risk of IDH. In this 24-month retrospective observational analysis we studied the incidence of IDH in 45 stable hemodialysis patients who underwent conversion from 0.5 mmol/L DMg to 1.0 mmol/L. Mean serum Mg was 1.12 ± 0.03 mmol/L pre-conversion and changed to 1.35 ± 0.04 mmol/L post-conversion. In parallel, incidence of IDH showed a significant decrease from 1.59 ± 0.34 to 1.08 ±0.27 % comparing 12 months before and 12 months after DMg conversion. The incidence of muscle cramps and serum calcium showed a trend for reduction while other parameters were unchanged. In conclusion, switching patients from 0.5 mmol/L DMg to 1.0 mmol/L was associated with a significant improvement of IDH incidence without significant changes in other parameters that were analyzed in this study. Further studies are warranted to test the association between DMg and IDH in a prospective randomized fashion.</p>