Effects of Anabolic Androgenic Steroids on Renal Morphology in Rats

• Main Authors: Virginia A Aparicio (Author), Daniel Camiletti-Moirón (Author), Mohammed Tassi (Author), Elena Nebot (Author), Carlos de- Teresa (Author), Pilar Aranda (Author)
• Format: Book
• Published: Archives of Renal Diseases and Management - Peertechz Publications, 2017-06-26.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p><strong>Aim:</strong> To  investigate the long-term effects of anabolic androgenic steroids (AAS)  on renal status in rats.</p><p><strong>Methods: </strong>Twenty Wistar rats were distributed into 2 groups: AAS or placebo, for 3 months.The animal received 10mg/kg body weight of Stanozonol once a week by intramuscular injection in the gluteus, or saline solution as placebo. </p><p><strong>Results:</strong> Urinary  pH  was  more  acidic  in  the  AAS  compared  to  the  placebo  group  (p<0.05).  Kidney weight was 15% higher in the AAS compared to the placebo group (p<0.001). Renal glomerular area was 12% higher in the AAS compared to the placebo group (p=0.001). Animals injected with AAS also displayed a no significant but clinically relevant ~20% higher kidney interstitial connective tissue, glomerular tufts and mesangiums.</p><p><strong>Conclusion: </strong>Overall, AAS negatively affected urinary pH and kidney morphology leading to a worse renal status. More attention should be taken to the use of AAS among populations at high risk for kidney disease.</p>

DOI

10.17352/2455-5495.000024