Blood Catalase Activities, Catalase Gene Polymorphisms and Acatalasemia Mutations in Hungarian Patients with Diabetes Mellitus
<p><strong>Introduction:</strong> Catalase decomposes hydrogen peroxide into oxygen and water. Its low concentration could be involved in signaling while its high concentration is toxic.</p><p><strong>Aim:</strong> This short review discusses the association...
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Global Journal of Obesity, Diabetes and Metabolic Syndrome - Peertechz Publications,
2016-03-21.
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| Samenvatting: | <p><strong>Introduction:</strong> Catalase decomposes hydrogen peroxide into oxygen and water. Its low concentration could be involved in signaling while its high concentration is toxic.</p><p><strong>Aim:</strong> This short review discusses the association of blood catalase and diabetes mellitus in Hungarian diabetic patients.</p><p><strong>Results:</strong> Several cohort studies showed decreased blood catalase activity in type 2 diabetes and in gestational diabetes. </p><p>Among the catalase gene polymorphisms rs769217 showed a weak association with type 1 diabetes. Regarding rs1001179 polymorphism patients with TT genotype have a risk for lower life expectancy. </p><p>In acatalasemics the frequency of diabetes mellitus is higher (P˂0.001) than in the Hungarian population. 11 of 12 known Hungarian acatalasemia mutations are found in diabetic patients. Acatalasemia may be associated with a higher risk for diabetes mellitus especially for its type 2 form.</p><p>Acatalasemia mutations could explain the decreased (˂50%) blood catalase activities only in 17.4% of the cases. </p><p><strong>Conclusions:</strong> Blood catalase activity is decreased in type 2 and gestional diabetes. Patients with inherited catalase deficiency and known acatalasemia mutation are at higher risk of diabetes mellitus.</p><p>The lifelong effect of oxidative damage on the oxidant sensitive, insulin producing pancreatic beta-cells could contribute to the manifestation of diabetes mellitus especially to type 2 form.</p><p>Acatalasemia mutations could explain the reason for the catalase decrease while for the other (82.6 %) cases it remains unsolved.</p><p>The decreased blood catalase activity in type 2 and gestational diabetes rather due to regulatory mechanisms than to the catalase gene mutations.</p> |
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| DOI: | 10.17352/2455-8583.000011 |