Glucose and insulin levels' linkages with breast cancer factors

<p>Serum lipid and  glucose metabolisms are considered as the intermediary mechanisms for connecting obesity and Breast Cancer (BC). The article aims to identify the linkages between diabetes biochemical factors such as glucose & insulin and BC biochemical factors such as Monocyte Chemoatt...

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Main Authors: Mahashweta Das (Author), Ishita Saha (Author), Prasenjit Sinha (Author), Sunit Kumar Medda (Author), Rabindra Nath Das (Author)
Format: Book
Published: Global Journal of Obesity, Diabetes and Metabolic Syndrome - Peertechz Publications, 2022-03-29.
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LEADER 00000 am a22000003u 4500
001 peertech__10_17352_2455-8583_000057
042 |a dc 
100 1 0 |a Mahashweta Das  |e author 
700 1 0 |a  Ishita Saha  |e author 
700 1 0 |a  Prasenjit Sinha  |e author 
700 1 0 |a  Sunit Kumar Medda  |e author 
700 1 0 |a Rabindra Nath Das  |e author 
245 0 0 |a Glucose and insulin levels' linkages with breast cancer factors 
260 |b Global Journal of Obesity, Diabetes and Metabolic Syndrome - Peertechz Publications,   |c 2022-03-29. 
520 |a <p>Serum lipid and  glucose metabolisms are considered as the intermediary mechanisms for connecting obesity and Breast Cancer (BC). The article aims to identify the linkages between diabetes biochemical factors such as glucose & insulin and BC biochemical factors such as Monocyte Chemoattractant Protein-1 (MCP-1), adiponectin, Homeostasis Model Assessment score Insulin Resistance (HOMA-IR), resistin, leptin. These objectives can be focused on  the two separate statistical models of glucose & insulin based on the remaining factors. From the mean model of glucose, it is observed that mean glucose level is directly linked with BC women (P= 0.023), leptin (P<0.001), HOMA-IR (P<0.001), while it is inversely linked with the interaction effects between HOMA-IR & leptin (i.e., HOMA-IR*leptin (P<0.001)) and adiponectin & leptin (i.e., adiponectin* leptin (P= 0.088)). Similarly, from the mean model of insulin, it is observed that mean insulin level is directly linked with HOMA-IR (P<0.001), leptin (P<0.001), and the interaction effects Age*MCP-1 (P= 0.091), glucose*adiponectin (P= 0.043), glucose*resistin (P<0.001), MCP-1*HOMA-IR (P<0.001), while it is reciprocally linked with MCP-1 (P= 0.026), resistin (P<0.001), adiponectin (P= 0.078), HOMA-IR*body mass index (BMI) (P<0.001), glucose*HOMA-IR (P<0.001), leptin*adiponectin (P= 0.071). There are more linkages of the variances of insulin and glucose with the BC biochemical factors. Based on the summarized results it is interpreted that diabetes biochemical factors such as insulin and glucose are highly linked with BC biomarkers such as MCP-1, HOMA-IR, leptin, resistin, and adiponectin.</p> 
540 |a Copyright © Mahashweta Das et al. 
546 |a en 
655 7 |a Research Article  |2 local 
856 4 1 |u https://doi.org/10.17352/2455-8583.000057  |z Connect to this object online.