Cytokine Production and Human Cytomegalovirus Load in Allogeneic Hematopoietic Stem Cell Transplantation Outcome

• Main Authors: TA Silva (Author), JF Correia-Silva (Author), RG Resende (Author), MHNG Abreu (Author), AL Teixeira (Author), H Bittencourt (Author), RS Gomez (Author)
• Format: Book
• Published: International Journal of Immunotherapy and Cancer Research - Peertechz Publications, 2016-06-17.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p><strong>Objective: </strong>To investigate the impact of cytokine levels (IL-1β, IL-6, IL-10, IFN-γ and TNF-α) and Human cytomegalovirus (HCMV) load in the saliva and blood on the survival of  llogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients.</p><p><strong></strong><strong>Study Design:</strong> Samples were obtained from 63 patients 7 days before and 21 days after allo-HSCT. Cytokine levels were assessed by ELISA, and HCMV load was determined by real- me PCR.</p><p><strong>Results: </strong>The increase of IL-6 in the saliva and the reduction of IFN-γ in the blood before allo-HSCT were associated with increased risk of death. Moreover, the increase of IL-6 in the blood and of HCMV in the saliva after allo-HSCT were also associated with increased risk of death.</p><p><strong>Conclusions:</strong> Cytokine levels and HCMV load were associated with the increased risk of death. The findings suggest a potential function of these biomarkers in the determination of allo-HSCT survival.</p>

DOI

10.17352/2455-8591.000008