Cytokine Production and Human Cytomegalovirus Load in Allogeneic Hematopoietic Stem Cell Transplantation Outcome

<p><strong>Objective: </strong>To investigate the impact of cytokine levels (IL-1β, IL-6, IL-10, IFN-γ and TNF-α) and Human cytomegalovirus (HCMV) load in the saliva and blood on the survival of  llogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients.</p><...

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Päätekijät: TA Silva (Tekijä), JF Correia-Silva (Tekijä), RG Resende (Tekijä), MHNG Abreu (Tekijä), AL Teixeira (Tekijä), H Bittencourt (Tekijä), RS Gomez (Tekijä)
Aineistotyyppi: Kirja
Julkaistu: International Journal of Immunotherapy and Cancer Research - Peertechz Publications, 2016-06-17.
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001 peertech__10_17352_2455-8591_000008
042 |a dc 
100 1 0 |a TA Silva  |e author 
700 1 0 |a  JF Correia-Silva  |e author 
700 1 0 |a  RG Resende  |e author 
700 1 0 |a  MHNG Abreu  |e author 
700 1 0 |a  AL Teixeira  |e author 
700 1 0 |a  H Bittencourt  |e author 
700 1 0 |a  RS Gomez  |e author 
245 0 0 |a Cytokine Production and Human Cytomegalovirus Load in Allogeneic Hematopoietic Stem Cell Transplantation Outcome 
260 |b International Journal of Immunotherapy and Cancer Research - Peertechz Publications,   |c 2016-06-17. 
520 |a <p><strong>Objective: </strong>To investigate the impact of cytokine levels (IL-1β, IL-6, IL-10, IFN-γ and TNF-α) and Human cytomegalovirus (HCMV) load in the saliva and blood on the survival of  llogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients.</p><p><strong></strong><strong>Study Design:</strong> Samples were obtained from 63 patients 7 days before and 21 days after allo-HSCT. Cytokine levels were assessed by ELISA, and HCMV load was determined by real- me PCR.</p><p><strong>Results: </strong>The increase of IL-6 in the saliva and the reduction of IFN-γ in the blood before allo-HSCT were associated with increased risk of death. Moreover, the increase of IL-6 in the blood and of HCMV in the saliva after allo-HSCT were also associated with increased risk of death.</p><p><strong>Conclusions:</strong> Cytokine levels and HCMV load were associated with the increased risk of death. The findings suggest a potential function of these biomarkers in the determination of allo-HSCT survival.</p> 
540 |a Copyright © TA Silva et al. 
546 |a en 
655 7 |a Research Article  |2 local 
856 4 1 |u https://doi.org/10.17352/2455-8591.000008  |z Connect to this object online.