Low PD-1 expression and no prognostic impact in early-stage Mycosis Fungoides: 61 patients retrospective cohort analysis
<p><strong>Background</strong>: Mycosis fungoides (MF) is an indolent behavior cutaneous T-cell lymphoma. Most patients present a slowly progressive course, over many years. However, some patients evolve early towards advanced stages of the disease, despite adequate treatment, havi...
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Main Authors: | , , , , , , , , |
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Format: | Book |
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International Journal of Dermatology and Clinical Research - Peertechz Publications,
2019-07-20.
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Summary: | <p><strong>Background</strong>: Mycosis fungoides (MF) is an indolent behavior cutaneous T-cell lymphoma. Most patients present a slowly progressive course, over many years. However, some patients evolve early towards advanced stages of the disease, despite adequate treatment, having therefore, a worse prognosis. Increasing knowledge of risk factors that contribute to a better prognostic evaluation is considered of interest.</p><p><strong>Aims</strong>: Evaluate positivity and prognostic importance of PD-1 marker in early-stage MF. <strong><br></strong></p><p><strong>Methods</strong>: Retrospective cohort study with early-stage MF patients. Cases were defi ned by Pimpinelli criteria. PD-1 positivity was tested in complementary immunohistochemistry over the fi rst skin biopsies done in our hospital. Disease progression, death and MF-related death was investigated 5 years after the date of the diagnostic defi nition according to the proposed criteria. The hazard ratio was calculated as association measurement. Adopted signifi cance criterion was 5%.</p> |
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DOI: | 10.17352/2455-8605.000032 |