Low PD-1 expression and no prognostic impact in early-stage Mycosis Fungoides: 61 patients retrospective cohort analysis

• Main Authors: Gustavo Moreira Amorim1 (Author), 2 (Author), 3 (Author), Danielle Carvalho Quintella1 (Author), João Paulo Niemeyer Corbellini1 (Author), Luiz Claudio Ferreira4 (Author), Marcia Ramos- (Author), Tullia Cuzzi1 (Author), 4 (Author)
• Format: Book
• Published: International Journal of Dermatology and Clinical Research - Peertechz Publications, 2019-07-20.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Background</strong>: Mycosis fungoides (MF) is an indolent behavior cutaneous T-cell lymphoma. Most patients present a slowly progressive course, over many years. However, some patients evolve early towards advanced stages of the disease, despite adequate treatment, having therefore, a worse prognosis. Increasing knowledge of risk factors that contribute to a better prognostic evaluation is considered of interest.</p><p><strong>Aims</strong>: Evaluate positivity and prognostic importance of PD-1 marker in early-stage MF. <strong><br></strong></p><p><strong>Methods</strong>: Retrospective cohort study with early-stage MF patients. Cases were defi ned by Pimpinelli criteria. PD-1 positivity was tested in complementary immunohistochemistry over the fi rst skin biopsies done in our hospital. Disease progression, death and MF-related death was investigated 5 years after the date of the diagnostic defi nition according to the proposed criteria. The hazard ratio was calculated as association measurement. Adopted signifi cance criterion was 5%.</p>