Stress and Glucose metabolism: A Review

• Main Authors: Nirupama R (Author), Barathi Rajaraman (Author), Yajurvedi HN (Author)
• Format: Book
• Published: Imaging Journal of Clinical and Medical Sciences - Peertechz Publications, 2018-03-29.
• Subjects: Mini Review
• Online Access: Connect to this object online.

<p>Stress is an inescapable fact of life. The perceived stress induces endocrine alterations characterized</p><p>by the activation of hypothalamo-pituitary-adrenal axis and sympathetic adreno-medullary axis. The</p><p>glucocorticoids and catecholamines which are secreted in response to stress induce variations in the</p><p>physiology and behavior that help the individual to adapt to changing demands of the body. Glucocorticoids</p><p>are known to play a central role in inducing the stress related pathophysiology. These hormones induce</p><p>hypermetabolism in order to cope up with the increasing energy demands of the body. However when the</p><p>stress is persistent the body adapts itself to continuous demands and starts regulating the metabolism</p><p>at higher levels than the normal, termed as allostasis. This overwhelming load on the body will predispose</p><p>the individual for the development of diseases. This mini-review focuses on long term chronic stress</p><p>induced alterations in glucose metabolism and development of insulin resistance and glucose intolerance</p><p>as a result of long term allostatic regulation.</p>