Improving measured health-related quality of life with outpatient high-dose methotrexate regimen among oncology patients with intracranial metastases: A systematic assessment
<p>Intracranial metastases including leptomeningeal disease are not uncommon in patients with metastatic solid tumor cancers, such as breast and sarcoma. Treatment options are limited with disease progression on standard-of-care therapies, and high-dose Methotrexate (MTX) is offered for patie...
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Archives of Nursing Practice and Care - Peertechz Publications,
2023-12-30.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_2581-4265_000065 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Heun Min |e author |
| 700 | 1 | 0 | |a Elizabeth Weil |e author |
| 700 | 1 | 0 | |a Maggie Nelson |e author |
| 700 | 1 | 0 | |a John Charlson |e author |
| 700 | 1 | 0 | |a Yee Chung Cheng |e author |
| 700 | 1 | 0 | |a Lubna N Chaudhary |e author |
| 700 | 1 | 0 | |a John Burfeind |e author |
| 700 | 1 | 0 | |a Janet Retseck |e author |
| 700 | 1 | 0 | |a Deepika Sriram |e author |
| 700 | 1 | 0 | |a Sailaja Kamaraju |e author |
| 245 | 0 | 0 | |a Improving measured health-related quality of life with outpatient high-dose methotrexate regimen among oncology patients with intracranial metastases: A systematic assessment |
| 260 | |b Archives of Nursing Practice and Care - Peertechz Publications, |c 2023-12-30. | ||
| 520 | |a <p>Intracranial metastases including leptomeningeal disease are not uncommon in patients with metastatic solid tumor cancers, such as breast and sarcoma. Treatment options are limited with disease progression on standard-of-care therapies, and high-dose Methotrexate (MTX) is offered for patients with well-preserved performance status. However, standard high-dose MTX treatment entails a lengthy hospitalization and close monitoring which can limit Quality of Life (QoL) for patients who already have multiple provider visits. The impact of high-dose MTX on patients' daily lives has not yet been qualitatively examined. As a quality improvement project, our team designed an outpatient high-dose protocol for patients who tolerated at least one cycle of inpatient high-dose MTX, and herein we describe the protocol and a quality survey with patients' feedback. The purpose of this study is to explore and compare the influence of high-dose MTX treatments in two different settings - inpatient and ambulatory - on patients' QoL. Second, we aim to identify recurrent themes defining patients' perceived QoL and healthcare experiences. This study identified key QoL impacts that high-dose MTX treatments have on metastatic breast and sarcoma patients. Patients experienced decreased health-related burdens and improved social and psychosocial well-being associated with high-dose MTX treatment compared to standard inpatient treatment. This study provides an opportunity to identify recurrent thematic domains defining QoL in women with metastatic breast cancer.</p> | ||
| 540 | |a Copyright © Heun Min et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Research Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/2581-4265.000065 |z Connect to this object online. |