A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets

• Autori principali: Luba Tchertanov (Autore), Julie Ledoux (Autore)
• Natura: Libro
• Pubblicazione: Global Journal of Cancer Therapy - Peertechz Publications, 2022-10-07.
• Soggetti: Research Article
• Accesso online: Connect to this object online.

<p>Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream s...