Molecular Docking studies on possible Neuraminidase Inhibitors of Influenza Virus

• Main Authors: Jawaria Khan (Author), Ardas Masood (Author), Asma Noor (Author), Anam Munir (Author), Muhammad Imran Qadir (Author)
• Format: Book
• Published: Annals of Antivirals and Antiretrovirals - Peertechz Publications, 2017-10-10.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Background: </strong>Influenza generally known as flu is due to viruses that contaminate the respiratory region. It can result in light to cruel sickness, and may cause death. The influenza pandemic of 1918-1919 took life of a lot more people than the World War 1. Peramivir that inhibits the purpose of the viral neuraminidase protein of influenza virus, therefore stopping the virus from replicating through budding from the host cell has been shown to have hindrance against virus. The neuraminidase enzyme is a glycoside hydrolyses enzyme that is shown on the exterior. It allows the virus to be free from the host cell and slice sialic acid groups from glycoproteins and is necessary for influenza virus reproduction.</p><p><strong>Methods: </strong>This study concentrates on the in silico virtual screening and molecular docking examination for probable neuraminidase blockers by peramivir like compounds recovered by the ZINC database. ADME-Toxicity examination is done by in silico methods.</p><p><strong>Results:</strong> Molecular docking outcomes propose that modified ligand Anamivire have improved binding attraction than peramivir and its derivatives i.e. ZINC3981610, ZINC 40709762.</p><p><strong>Conclusion: </strong>Modified ligand Anamivire is shown to have resistance against neuraminidase enzyme and bioavailability troubles than ZINC3981610, ZINC40709762 and peramivir.</p>