Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach

• প্রধান লেখক: Muhammad Imran Qadir (Author), Asma Munawar (Author), Syed Bilal Hussain (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Annals of Antivirals and Antiretrovirals - Peertechz Publications, 2018-01-17.
• বিষয়গুলি: Research Article
• অনলাইন ব্যবহার করুন: Connect to this object online.

সংক্ষিপ্ত

<p>Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydrogen bonding as well as hydrophobic interactions. Its binding energy after modification (Thiolutin1) was -6.7 kcal/mol, which was greater than the original thiolutin affinity.</p>

ডিওআই

10.17352/aaa.000003