Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach
<p>Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydroge...
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Annals of Antivirals and Antiretrovirals - Peertechz Publications,
2018-01-17.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_aaa_000003 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Muhammad Imran Qadir |e author |
| 700 | 1 | 0 | |a Asma Munawar |e author |
| 700 | 1 | 0 | |a Syed Bilal Hussain |e author |
| 245 | 0 | 0 | |a Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach |
| 260 | |b Annals of Antivirals and Antiretrovirals - Peertechz Publications, |c 2018-01-17. | ||
| 520 | |a <p>Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydrogen bonding as well as hydrophobic interactions. Its binding energy after modification (Thiolutin1) was -6.7 kcal/mol, which was greater than the original thiolutin affinity.</p> | ||
| 540 | |a Copyright © Muhammad Imran Qadir et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Research Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/aaa.000003 |z Connect to this object online. |