Amyloid-beta clearance in Alzheimer's disease: Does exercise play a role?

• Main Authors: Reza Gharakhanlou (Author), Davar Khodadadi (Author)
• Format: Book
• Published: Annals of Alzheimer's and Dementia Care - Peertechz Publications, 2020-09-14.
• Subjects: Commentary
• Online Access: Connect to this object online.

Summary

<p>Alzheimer's Disease (AD), the most common form of dementia, is characterized by progressive deficits in cognitive function. Amyloid-beta (Aβ) peptides are believed to play a decisive role in the pathology of AD. Improving the clearance of toxic Aβ has, therefore, become a therapeutic strategy for AD. Unfortunately, almost all of the drug candidates tested for AD, including the Aβ centric therapeutic approaches, until now have failed to exhibit any efficacy. Previous evidence suggested that aerobic exercise training contributes to the improvement of cognitive decline and slows down pathogenesis of AD; however, the exact mechanisms for this have not been fully understood. One of the most important beneficial effects of aerobic exercise on AD is modifying Aβ clearance. Accumulating evidence indicates that aerobic exercise not only upregulates the clearance of amyloid plaques and soluble Aβ in the brain but also increases its final removal from the periphery. But there are still many unanswered questions in this regard, including the proper timing of exercise interventions, optimal aerobic exercise mode, intensity, duration, and frequency as well as the possible effect of exercise on potential environmental Aβ-clearing agents, which should be considered in future studies.</p>

DOI

10.17352/aadc.000013