T-ALL with TEL/AML1 Translocation, Aberrant Expression of CD19 and 33: Case Report and Literature Review
<p>We herewith introduce a 9-year-old boy presenting with leukocytosis, anemia and high lymphoblast count who had a pale complexion as well as weight loss. His cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XY karyotype with t (12;...
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Main Authors: | , , , , , , |
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Format: | Book |
Published: |
Annals of Bone Marrow Research - Peertechz Publications,
2016-12-14.
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Online Access: | Connect to this object online. |
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Summary: | <p>We herewith introduce a 9-year-old boy presenting with leukocytosis, anemia and high lymphoblast count who had a pale complexion as well as weight loss. His cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XY karyotype with t (12; 21) (p12; q22), which was confirmed by DNA sequencing. Flowcytometry assay detected aberrant B lymphocyte and myeloid CD markers such as CD19 (22.0%) and CD33 (20.5%), respectively. To our knowledge, this is the first case of a patient initially diagnosed as TEL/AML1 transcript positive T-ALL expressing CD19 and CD33 markers. The present article also highlights the need for molecular gene rearrangement studies to determine the precise lineage of ambiguous ALL clones.</p> |
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DOI: | 10.17352/abmr.000001 |