T-ALL with TEL/AML1 Translocation, Aberrant Expression of CD19 and 33: Case Report and Literature Review
<p>We herewith introduce a 9-year-old boy presenting with leukocytosis, anemia and high lymphoblast count who had a pale complexion as well as weight loss. His cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XY karyotype with t (12;...
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Annals of Bone Marrow Research - Peertechz Publications,
2016-12-14.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_abmr_000001 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Kave Jasseb |e author |
700 | 1 | 0 | |a Maria Kavianpour |e author |
700 | 1 | 0 | |a Javad Mohammadi Asl |e author |
700 | 1 | 0 | |a Zahra Shahpouri Arani |e author |
700 | 1 | 0 | |a Vahid Fallah Azad |e author |
700 | 1 | 0 | |a Mansoureh Haghighi |e author |
700 | 1 | 0 | |a Najmaldin Saki |e author |
245 | 0 | 0 | |a T-ALL with TEL/AML1 Translocation, Aberrant Expression of CD19 and 33: Case Report and Literature Review |
260 | |b Annals of Bone Marrow Research - Peertechz Publications, |c 2016-12-14. | ||
520 | |a <p>We herewith introduce a 9-year-old boy presenting with leukocytosis, anemia and high lymphoblast count who had a pale complexion as well as weight loss. His cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XY karyotype with t (12; 21) (p12; q22), which was confirmed by DNA sequencing. Flowcytometry assay detected aberrant B lymphocyte and myeloid CD markers such as CD19 (22.0%) and CD33 (20.5%), respectively. To our knowledge, this is the first case of a patient initially diagnosed as TEL/AML1 transcript positive T-ALL expressing CD19 and CD33 markers. The present article also highlights the need for molecular gene rearrangement studies to determine the precise lineage of ambiguous ALL clones.</p> | ||
540 | |a Copyright © Kave Jasseb et al. | ||
546 | |a en | ||
655 | 7 | |a Case Report |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/abmr.000001 |z Connect to this object online. |