Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates
<p>Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroqui...
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Main Authors: | , , , , |
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Format: | Book |
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Archive of Biomedical Science and Engineering - Peertechz Publications,
2018-12-21.
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Online Access: | Connect to this object online. |
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Summary: | <p>Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good-moderate antibacterial activity.</p> |
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DOI: | 10.17352/abse.000009 |