Fever Induced Brugada Syndrome
<p>Brugada syndrome is a heterogeneous genetic channelopathy that predisposes to ventricular arrhythmias and sudden cardiac death (SCD). The electrocardiogram (ECG) findings only suggest a diagnosis of Brugada syndrome but are not confirmatory. The ECG pattern is known to vary with time in som...
Saved in:
Main Author: | |
---|---|
Format: | Book |
Published: |
Annals of Circulation - Peertechz Publications,
2017-07-03.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | <p>Brugada syndrome is a heterogeneous genetic channelopathy that predisposes to ventricular arrhythmias and sudden cardiac death (SCD). The electrocardiogram (ECG) findings only suggest a diagnosis of Brugada syndrome but are not confirmatory. The ECG pattern is known to vary with time in some patients and many have a normal baseline ECG [1,2]. There are two distinctly described ECG patterns, type I Brugada is characterized by ST elevation (≥2mm) with a "coved" pattern or a T-wave which is inverted with an upward convexity, in other cases the elevated ST segment descends and rises again forming a "saddleback" type pattern, this is called the type II Brugada. The electrophysiological and clinical manifestations of this syndrome have been found to be secondary to various factors [3-10]. Of these, mutations in cardiac sodium channel SCN genes (SCN5A and SCN10A) are the most well-known [11]. Since all affected families do not have these mutations, it is believed that other mutations in sodium channel genes or mutations in non-sodium channel genes may also cause Brugada syndrome [12-15].</p> |
---|---|
DOI: | 10.17352/ac.000008 |