High incidence rate of human herpesvirus 6 infection after Bendamustine, Cytarabine, Etoposide and Melphalan conditioning regimen: A monocentric and retrospective study
<p>Background: Following shortage of Carmustine, BeEAM regimen (Bendamustine, Etoposide, Cytarabine and Melphalan) was used before autologous transplant in relapsed/refractory lymphoma patients. We evaluated safety and efficacy of BeEAM compared to BEAM.</p><p>Patients and methods:...
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Archives of Clinical Nephrology - Peertechz Publications,
2021-06-14.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_acn_000054 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Simon Favre |e author |
700 | 1 | 0 | |a Mathieu Sauvezie |e author |
700 | 1 | 0 | |a Stéphane Vigouroux |e author |
700 | 1 | 0 | |a Reza Tabrizi |e author |
700 | 1 | 0 | |a Marie-Sarah Dilhuydy |e author |
700 | 1 | 0 | |a Gaelle Laboure |e author |
700 | 1 | 0 | |a Margot Robles |e author |
700 | 1 | 0 | |a Noel Milpied |e author |
700 | 1 | 0 | |a Kamal Bouabdallah |e author |
245 | 0 | 0 | |a High incidence rate of human herpesvirus 6 infection after Bendamustine, Cytarabine, Etoposide and Melphalan conditioning regimen: A monocentric and retrospective study |
260 | |b Archives of Clinical Nephrology - Peertechz Publications, |c 2021-06-14. | ||
520 | |a <p>Background: Following shortage of Carmustine, BeEAM regimen (Bendamustine, Etoposide, Cytarabine and Melphalan) was used before autologous transplant in relapsed/refractory lymphoma patients. We evaluated safety and efficacy of BeEAM compared to BEAM.</p><p>Patients and methods: Ninety consecutive patients receiving BeEAM (30pts) (Bendamustine 100, 120 or 200 mg/m²/d) or BEAM (60 pts) were retrospectively analyzed. </p><p>Results: In the BEAM group, 68% had NHL and 32% HL compared to 87% and 13% in the BeEAM group (p = 0,014). Pts were in CR or PR at time of transplant. There was no difference regarding hematologic recovery and transfusion requirements. Highest dose of Bendamustine were associated with grade ≥ 2 kidney toxicity. We observed a significant higher incidence of symptomatic HHV-6 infection (53.3% versus 8.3%), digestive toxicity (36.6% versus 15%) and prolonged hospitalization (25 versus 21 days) with BeEAM. After a median follow up of 61 and 49 months for BEAM and BeEAM, 5y-OS and PFS (76% versus 67% and 56% versus 70%) and TRM (0% versus 3%) were not different.</p><p>Conclusions: BeEAM with the highest doses of Bendamustine was associated with increased risk of HHV-6 infection, longer duration of hospitalization, higher rate of digestive toxicity and increased acute kidney failure while survival was comparable.</p> | ||
540 | |a Copyright © Simon Favre et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/acn.000054 |z Connect to this object online. |