Immunohistochemical Analysis and Pathological Assessment of B-Cbl Proto-Oncogene in Gastric Carcinoma Cells
<p><strong>Objective: </strong>In order to study the status and the expression of Cbl-b onco-protein in gastric carcinoma we underwent an immunohistochemical protocol by which we analyzed the immunodistribution as well as the level of Cbl-b expression on gastric cancerous tissues....
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Annals of Cytology and Pathology - Peertechz Publications,
2016-08-26.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_acp_000008 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Noria Harir |e author |
| 700 | 1 | 0 | |a Rachida Salah |e author |
| 700 | 1 | 0 | |a Malika Aidouni |e author |
| 700 | 1 | 0 | |a Miloud Medjamia |e author |
| 700 | 1 | 0 | |a Nesrine Mrabent |e author |
| 700 | 1 | 0 | |a Soumia Zeggai |e author |
| 700 | 1 | 0 | |a Mustapha Diaf |e author |
| 245 | 0 | 0 | |a Immunohistochemical Analysis and Pathological Assessment of B-Cbl Proto-Oncogene in Gastric Carcinoma Cells |
| 260 | |b Annals of Cytology and Pathology - Peertechz Publications, |c 2016-08-26. | ||
| 520 | |a <p><strong>Objective: </strong>In order to study the status and the expression of Cbl-b onco-protein in gastric carcinoma we underwent an immunohistochemical protocol by which we analyzed the immunodistribution as well as the level of Cbl-b expression on gastric cancerous tissues.</p><p><strong>Material and method:</strong> Ninety-six (96) paraffin blocks of cancerous gastric tissues sections were collected from the Department of pathology, of Oran Military Hospital (Western Algeria) for the period of 2006-2015. All the cases were identified histologically as malignant gastric cells. An immunohistochemical protocol to analyze the expression of Cbl-b in gastric cancerous tissues.</p><p><strong>Results:</strong> Our immunohistochemical analysis revealed that Cbl-b protein was expressed in gastric cancerous cells with different immune-scoring and different immunostaining intensity. The most predominant observed score was score 0 in 37 cases (38.5%) followed by score 2 in 13 cases (13.5%); then score 4 in 11 cases (11.5%). The least predominant scores were score 6 in 7 cases (7.3%), than score 1, 5 and 7 with the same number of cases 6 (6.3%). Concerning immunostaining levels; we reported an intense staining in 14 cases (14.6%); a moderate staining in 16 cases (16.7%); a poor staining in 14 cases (14.6%) and no staining in 52 cases (54.2%). <strong><br></strong></p><p><strong>Conclusion:</strong> Cbl-b oncoprotein is immunohistochemically expressed in human gastric carcinoma.More surveys are required to determine the role of Cbl-b in non-hematopoeitic cell systems.</p> | ||
| 540 | |a Copyright © Noria Harir et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Research Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/acp.000008 |z Connect to this object online. |