Micronucleus scoring: An available approach in the evaluation of genomic damage in exfoliative cervicovaginal cells
<p>Micronucleus is small chromatin extranuclear bodies when chromosomes or chromosomal fragments are not included in the nucleus during cell division. Micronucleus formation usually serves as a sensible indicator of genotoxic damage and also a morphological marker of chromosomal instability. G...
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| প্রধান লেখক: | |
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| বিন্যাস: | গ্রন্থ |
| প্রকাশিত: |
Annals of Cytology and Pathology - Peertechz Publications,
2020-06-22.
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| অনলাইন ব্যবহার করুন: | Connect to this object online. |
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| সংক্ষিপ্ত: | <p>Micronucleus is small chromatin extranuclear bodies when chromosomes or chromosomal fragments are not included in the nucleus during cell division. Micronucleus formation usually serves as a sensible indicator of genotoxic damage and also a morphological marker of chromosomal instability. Genomic damage is crucial for the development of degenerative diseases, including cancer. MN assay is a reliable and applicable method on many cell types such as erythrocytes, leucocytes and epithelial cells and it represents an important tool for evaluating DNA damage and defects in mitosis. The purpose of this article is to provide an overview of the current status of the micronuclei scoring in exfoliated epithelial cells and to highlight the importance of this procedure. </p> |
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| ডিওআই: | 10.17352/acp.000018 |