The correlation between serum cytokine levels and liver cirrhosis in chronic hepatitis B patients: A meta-analysis

<p>Background: The harm of liver cirrhosis (LC) is serious, and the development of LC is primarily resulted from chronic hepatitis B virus (HBV) in high-risk such as China and Africa and chronic hepatitis C virus (HCV) in developed areas such as United States. Currently, there were 360 million...

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Main Authors: Gaofeng Cai (Author), Zhengting Wang (Author), Jun Yao (Author), Kui Liu (Author), Zhifang Wang (Author), Yongdi Chen (Author), Huakun Lv (Author), Biao Zhou (Author), Chonggao Hu (Author)
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Izdano: Archives of Hepatitis Research - Peertechz Publications, 2018-10-25.
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LEADER 00000 am a22000003u 4500
001 peertech__10_17352_ahr_000019
042 |a dc 
100 1 0 |a Gaofeng Cai  |e author 
700 1 0 |a  Zhengting Wang  |e author 
700 1 0 |a  Jun Yao  |e author 
700 1 0 |a  Kui Liu  |e author 
700 1 0 |a  Zhifang Wang  |e author 
700 1 0 |a  Yongdi Chen  |e author 
700 1 0 |a  Huakun Lv  |e author 
700 1 0 |a  Biao Zhou  |e author 
700 1 0 |a  Chonggao Hu  |e author 
245 0 0 |a The correlation between serum cytokine levels and liver cirrhosis in chronic hepatitis B patients: A meta-analysis 
260 |b Archives of Hepatitis Research - Peertechz Publications,   |c 2018-10-25. 
520 |a <p>Background: The harm of liver cirrhosis (LC) is serious, and the development of LC is primarily resulted from chronic hepatitis B virus (HBV) in high-risk such as China and Africa and chronic hepatitis C virus (HCV) in developed areas such as United States. Currently, there were 360 million chronic HBV-infected people on a global scale, and 30 million chronic hepatitis B (CHB) patients in China. In general, cytokines can regulate immune responses or contribute to deleterious tissue injury. However, the effects of these cytokines reported were controversial. Therefore, we executed a meta-analysis evaluating whether these cytokines can change the development risk of LC. </p><p>Methods: CHB patients were taken as participants, and studies were searched from Springer, Wiley, Chinese Medical Journal Database, PubMed, Elsevier, OVID, EBSCO, Mean difference (MD) with 95% confidence intervals (CI) were calculated by Review Manager 5.1.</p><p>Results: In this meta-analysis, 731cases and 1012 controls from 30 studies were analyzed. The pooled MD of the serum cytokines were transforming growth factor-β1 (TGF-β1): 25.86 (95% CI : 184.73-286.99)pg/ml, interleukin(IL)-6: 56.35 (95% CI : 19.00-93.70) pg/ml, IL-17:22.07(95% CI : 11.77-32.37) pg/ml, IL-10:-3.24 (95% CI : -4.11, -2.36) pg/ml, and interferon-γ (IFN-γ): 1.50(95% CI : -4.34-7.35) pg/ml, respectively.</p><p>Discussion: In CHB patients, elevated of serum levels for TGF-β, IL-6, and IL-17 can increase the risk of LC development, whereas elevated of serum levels for IL-10 decreased the risk. We suggest high-risk subjects with elevated of serum levels for these cytokines should be closely monitored and receive treatment timely for reducing the development of LC.</p> 
540 |a Copyright © Gaofeng Cai et al. 
546 |a en 
655 7 |a Research Article  |2 local 
856 4 1 |u https://doi.org/10.17352/ahr.000019  |z Connect to this object online.