Lipid nanoparticulate drug delivery system for the treatment of hepatic fibrosis
<p>Background: Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by hepatic stellate cells in the liver, becomes a remarkable economic burden in global health care system.Low therapeutic efficacy and undesirable systemic effect of conventional the...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Archives of Hepatitis Research - Peertechz Publications,
2021-01-28.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Background: Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by hepatic stellate cells in the liver, becomes a remarkable economic burden in global health care system.Low therapeutic efficacy and undesirable systemic effect of conventional therapies limit their clinical applications to targethepatic stellate cells.</p><p>Method: Surface engineered lipid nano-particle becomes a potential candidate to deliver anti-fibrotic nutrients or Small interfering RNA (siRNA) of fibrogenic genes for treating hepatic disorders. </p><p>Conclusion: This mini review focuses on different strategies of surface engineered organic lipid nanoparticles for the treatment of hepatic fibrosis by targeting specific and un-specific Hepatic Stellate Cells (HSCs).</p> |
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| DOI: | 10.17352/ahr.000028 |