Lipid nanoparticulate drug delivery system for the treatment of hepatic fibrosis
<p>Background: Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by hepatic stellate cells in the liver, becomes a remarkable economic burden in global health care system.Low therapeutic efficacy and undesirable systemic effect of conventional the...
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Archives of Hepatitis Research - Peertechz Publications,
2021-01-28.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_ahr_000028 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Swarupananda Mukherjee |e author |
| 700 | 1 | 0 | |a Ayon Dutta |e author |
| 700 | 1 | 0 | |a Dipanjana Ash |e author |
| 245 | 0 | 0 | |a Lipid nanoparticulate drug delivery system for the treatment of hepatic fibrosis |
| 260 | |b Archives of Hepatitis Research - Peertechz Publications, |c 2021-01-28. | ||
| 520 | |a <p>Background: Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by hepatic stellate cells in the liver, becomes a remarkable economic burden in global health care system.Low therapeutic efficacy and undesirable systemic effect of conventional therapies limit their clinical applications to targethepatic stellate cells.</p><p>Method: Surface engineered lipid nano-particle becomes a potential candidate to deliver anti-fibrotic nutrients or Small interfering RNA (siRNA) of fibrogenic genes for treating hepatic disorders. </p><p>Conclusion: This mini review focuses on different strategies of surface engineered organic lipid nanoparticles for the treatment of hepatic fibrosis by targeting specific and un-specific Hepatic Stellate Cells (HSCs).</p> | ||
| 540 | |a Copyright © Swarupananda Mukherjee et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Mini Review |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/ahr.000028 |z Connect to this object online. |