Nutritional intervention for cancer sarcopenia

• Main Authors: Takuya Mori (Author), Akira Kido (Author), Isao Kawahara (Author), Shota Nuaga (Author), Yoshihiro Miyagawa (Author), Kei Goto (Author), Shiori Mori (Author), Shingo Kishi (Author), Kiyomu Fujii (Author), Rina Fujiwara-Tani (Author), Hiroki Kuniyasu (Author)
• Format: Book
• Published: Annals of Musculoskeletal Medicine - Peertechz Publications, 2021-01-06.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p>Most patients with advanced cancer develop skeletal muscle atrophy called sarcopenia, which reduces treatment tolerance and social activity and worsens the prognosis. Glucose suppresses skeletal muscle atrophy in cancer-bearing mice, while promoting cancer growth. In contrast, medium-chain fatty acids reduce skeletal muscle atrophy and suppress cancer growth. Simultaneous administration of glucose and medium-chain fatty acids suppresses skeletal muscle atrophy and eliminates the tumor growth seen in glucose. Based on these findings, dietary intervention using a combination of glucose and medium-chain fatty acids is expected to be effective in suppressing sarcopenia in cancer patients.</p>

DOI

10.17352/amm.000024