Recurrence of Immunotactoid Glomerulopathy with Monoclonal IgG3κ Deposits after Kidney Transplant

• Egile Nagusiak: Katsuyuki Miki (Egilea), Maki Sumida (Egilea), Kazuhiro Iwadoh (Egilea), Kazuho Honda (Egilea), Toru Murakami (Egilea), Ichiro Koyama (Egilea), Ichiro Nakajima (Egilea), Shohei Fuchinoue (Egilea)
• Formatua: Liburua
• Argitaratua: Archives of Organ Transplantation - Peertechz Publications, 2017-06-30.
• Gaiak: Case Report
• Sarrera elektronikoa: Connect to this object online.

Gaia

<p>We report a case of rapid recurrence of immunotactoid glomerulopathy (ITG) with monoclonal IgG3κ deposits in a transplanted renal graft. A 55-year-old hemodialysis male patient due to ITG underwent an ABO-incompatible living-donor kidney transplantation. Proteinuria (3.11 g/day) and increased serum creatinine (2.52 mg/dL) were detected on postoperative day (POD) 4 due to acute antibody-mediated rejection (aAMR). Even after treatment for aAMR, proteinuria increased again to 4.5 g/day because of a recurrent ITG with IgG3κ subclass deposits. He returned to maintenance hemodialysis 9 months after transplantation. </p><p>This case underlines the importance of preoperative monoclonal paraproteinuria test to predict an ITG recurrence in the renal graft.</p>

DOI

10.17352/aot.000006